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Histamine H(3)-Receptor Signaling in Cardiac Sympathetic Nerves: Identification of a Novel MAPK-PLA(2)-COX-PGE(2)-EP(3)R Pathway

We tested the hypothesis that the histamine H(3)-receptor (H(3)R)-mediated attenuation of norepinephrine (NE) exocytosis from cardiac sympathetic nerves results not only from a Gα(i)-mediated inhibition of the adenylyl cyclase-cAMP-PKA pathway, but also from a Gβγ(i)-mediated activation of the MAPK-...

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Autors principals: Levi, Roberto, Seyedi, Nahid, Schaefer, Ulrich, Estephan, Rima, Mackins, Christina J., Tyler, Eleanor, Silver, Randi B.
Format: Artigo
Idioma:Inglês
Publicat: 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1893009/
https://ncbi.nlm.nih.gov/pubmed/17266940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2007.01.001
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