Coupling of histamine H(3) receptors to neuronal Na(+)/H(+) exchange: A novel protective mechanism in myocardial ischemia

In myocardial ischemia, adrenergic nerves release excessive amounts of norepinephrine (NE), causing dysfunction and arrhythmias. With anoxia and the concomitant ATP depletion, vesicular storage of NE is impaired, resulting in accumulation of free NE in the axoplasm of sympathetic nerves. Intraneuron...

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Detalhes bibliográficos
Main Authors: Silver, Randi B., Mackins, Christina J., Smith, Neil C. E., Koritchneva, Irina L., Lefkowitz, Kara, Lovenberg, Timothy W., Levi, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC30229/
https://ncbi.nlm.nih.gov/pubmed/11226330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051599198
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