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MULTIPLE ENHANCER REGIONS LOCATED AT SIGNIFICANT DISTANCES UPSTREAM OF THE TRANSCRIPTIONAL START SITE MEDIATE RANKL GENE EXPRESSION IN RESPONSE TO 1,25-DIHYDROXYVITAMIN D(3)
One of the primary regulators of Receptor activator of NF-κB ligand (RANKL) is 1,25-dihydoxyvitamin D(3) (1,25(OH)(2)D(3)). To elucidate the mechanism whereby 1,25(OH)(2)D(3) activates RANKL expression we screened some 300 kb of the RANKL gene locus using a ChIP on chip analysis and identified five...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1892901/ https://ncbi.nlm.nih.gov/pubmed/17197168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2006.12.020 |
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