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1,25-DIHYDROXYVITAMIN D(3) INDUCES EXPRESSION OF THE WNT SIGNALING CO-REGULATOR LRP5 VIA REGULATORY ELEMENTS LOCATED SIGNIFICANTLY DOWNSTREAM OF THE GENE’S TRANSCRIPTIONAL START SITE

Canonical Wnt signaling is essential for bone formation. Activation involves binding of secreted members of the Wnt family of proteins with a membrane receptor Frizzled on osteoblasts, an interaction that is facilitated by LRP5/LRP6 co-receptors. LRP5 is known to play a particularly important role i...

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Bibliografiske detaljer
Main Authors: Fretz, Jackie A., Zella, Lee A., Kim, Sungtae, Shevde, Nirupama K., Pike, J. Wesley
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868540/
https://ncbi.nlm.nih.gov/pubmed/17229572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2006.11.018
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