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1,25-DIHYDROXYVITAMIN D(3) INDUCES EXPRESSION OF THE WNT SIGNALING CO-REGULATOR LRP5 VIA REGULATORY ELEMENTS LOCATED SIGNIFICANTLY DOWNSTREAM OF THE GENE’S TRANSCRIPTIONAL START SITE
Canonical Wnt signaling is essential for bone formation. Activation involves binding of secreted members of the Wnt family of proteins with a membrane receptor Frizzled on osteoblasts, an interaction that is facilitated by LRP5/LRP6 co-receptors. LRP5 is known to play a particularly important role i...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1868540/ https://ncbi.nlm.nih.gov/pubmed/17229572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2006.11.018 |
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