Vitamin D-Binding Protein Influences Total Circulating Levels of 1,25-Dihydroxyvitamin D(3) but Does Not Directly Modulate the Bioactive Levels of the Hormone in Vivo

Mice deficient in the expression of vitamin D-binding protein (DBP) are normocalcemic despite undetectable levels of circulating 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)]. We used this in vivo mouse model together with cells in culture to explore the impact of DBP on the biological activity of 1,...

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Main Authors: Zella, Lee A., Shevde, Nirupama K., Hollis, Bruce W., Cooke, Nancy E., Pike, J. Wesley
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453093/
https://ncbi.nlm.nih.gov/pubmed/18372326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-0042
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