MULTIPLE ENHANCER REGIONS LOCATED AT SIGNIFICANT DISTANCES UPSTREAM OF THE TRANSCRIPTIONAL START SITE MEDIATE RANKL GENE EXPRESSION IN RESPONSE TO 1,25-DIHYDROXYVITAMIN D(3)

One of the primary regulators of Receptor activator of NF-κB ligand (RANKL) is 1,25-dihydoxyvitamin D(3) (1,25(OH)(2)D(3)). To elucidate the mechanism whereby 1,25(OH)(2)D(3) activates RANKL expression we screened some 300 kb of the RANKL gene locus using a ChIP on chip analysis and identified five...

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Détails bibliographiques
Auteurs principaux: Kim, Sungtae, Yamazaki, Miwa, Zella, Lee A., Meyer, Mark B., Fretz, Jackie A., Shevde, Nirupama K., Pike, J. Wesley
Format: Artigo
Langue:Inglês
Publié: 2007
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1892901/
https://ncbi.nlm.nih.gov/pubmed/17197168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2006.12.020
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