Ligand Binding and Circular Permutation Modify Residue Interaction Network in DHFR

Residue interaction networks and loop motions are important for catalysis in dihydrofolate reductase (DHFR). Here, we investigate the effects of ligand binding and chain connectivity on network communication in DHFR. We carry out systematic network analysis and molecular dynamics simulations of the...

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Detalhes bibliográficos
Main Authors: Hu, Zengjian, Bowen, Donnell, Southerland, William M, del Sol, Antonio, Pan, Yongping, Nussinov, Ruth, Ma, Buyong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1892607/
https://ncbi.nlm.nih.gov/pubmed/17571919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.0030117
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