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Residues crucial for maintaining short paths in network communication mediate signaling in proteins

Here, we represent protein structures as residue interacting networks, which are assumed to involve a permanent flow of information between amino acids. By removal of nodes from the protein network, we identify fold centrally conserved residues, which are crucial for sustaining the shortest pathways...

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Detalhes bibliográficos
Main Authors: del Sol, Antonio, Fujihashi, Hirotomo, Amoros, Dolors, Nussinov, Ruth
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1681495/
https://ncbi.nlm.nih.gov/pubmed/16738564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb4100063
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