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PINK1 Protects against Oxidative Stress by Phosphorylating Mitochondrial Chaperone TRAP1

Mutations in the PTEN induced putative kinase 1 (PINK1) gene cause an autosomal recessive form of Parkinson disease (PD). So far, no substrates of PINK1 have been reported, and the mechanism by which PINK1 mutations lead to neurodegeneration is unknown. Here we report the identification of TNF recep...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Pridgeon, Julia W, Olzmann, James A, Chin, Lih-Shen, Li, Lian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1892574/
https://ncbi.nlm.nih.gov/pubmed/17579517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0050172
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