Induction of calf thymus topoisomerase II-mediated DNA breakage by the antibacterial isothiazoloquinolones A-65281 and A-65282.

A number of quinolones and related antibacterial compounds were screened for activity against calf thymus topoisomerase II by using the P4 unknotting and DNA breakage assays. Several compounds from different structural classes which inhibited DNA unknotting with 50% inhibitory concentrations ranging...

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Publicado en:	Antimicrob Agents Chemother
Autores principales:	Kohlbrenner, W E, Wideburg, N, Weigl, D, Saldivar, A, Chu, D T
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1992
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189231/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1317151/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.36.1.81
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