TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation

Aberrant expression of the TCL1 oncoprotein promotes malignant transformation of germinal center (GC) B cells. Repression of TCL1 in GC B cells facilitates FAS-mediated apoptosis and prevents lymphoma formation. However, the mechanism for this repression is unknown. Here we show that the CREB coacti...

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Main Authors: Kuraishy, Ali I., French, Samuel W., Sherman, Mara, Herling, Marco, Jones, Dan, Wall, Randolph, Teitell, Michael A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1891214/
https://ncbi.nlm.nih.gov/pubmed/17548807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704170104
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