High TCL1 expression and intact T-cell receptor signaling define a hyperproliferative subset of T-cell prolymphocytic leukemia

The T-cell leukemia 1 (TCL1) oncoprotein is overexpressed by chromosomal rearrangement in the majority of cases of T-cell prolymphocytic leukemia (T-PLL). In vitro, TCL1 can modulate the activity of the serine-threonine kinase AKT, a downstream effector of T-cell receptor (TCR) signaling. In a serie...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Herling, Marco, Patel, Kaushali A., Teitell, Michael A., Konopleva, Marina, Ravandi, Farhad, Kobayashi, Ryuji, Jones, Dan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200815/
https://ncbi.nlm.nih.gov/pubmed/17890451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-07-101519
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados