Dysregulated TCL1 requires the germinal center and genome instability for mature B-cell transformation

Most lymphomas arise by transformation of germinal center (GC) B cells. TCL1, a proto-oncogene first recognized for its role in T-cell transformation, also induces GC B-cell malignancies when dysregulated in pEμ-B29-TCL1 transgenic (TCL1-tg) mice. Clonal B-cell lymphomas develop from polyclonal popu...

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Auteurs principaux: Shen, Rhine R., Ferguson, David O., Renard, Mathilde, Hoyer, Katrina K., Kim, Unkyu, Hao, Xingpei, Alt, Frederick W., Roeder, Robert G., Morse, Herbert C., Teitell, Michael A.
Format: Artigo
Langue:Inglês
Publié: The American Society of Hematology 2006
Sujets:
Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895536/
https://ncbi.nlm.nih.gov/pubmed/16728701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-02-001354
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