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TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation
Aberrant expression of the TCL1 oncoprotein promotes malignant transformation of germinal center (GC) B cells. Repression of TCL1 in GC B cells facilitates FAS-mediated apoptosis and prevents lymphoma formation. However, the mechanism for this repression is unknown. Here we show that the CREB coacti...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1891214/ https://ncbi.nlm.nih.gov/pubmed/17548807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704170104 |
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