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Ligand density dramatically affects integrin αIIbβ3-mediated platelet signaling and spreading

The impact of ligand density on integrin-mediated cell adhesion and outside-in signaling is not well understood. Using total internal reflection fluorescent microscopy, conformation-specific antibodies, and Ca(2+) flux measurements, we found that the surface density of fibrinogen affects αIIbβ3-medi...

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Bibliografiske detaljer
Main Authors: Jiroušková, Markéta, Jaiswal, Jyoti K., Coller, Barry S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1890822/
https://ncbi.nlm.nih.gov/pubmed/17332246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-10-054015
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