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An exonuclease I hydrolysis assay for evaluating G-quadruplex stabilization by small molecules
Telomere length homeostasis is a prerequisite for the generation and growth of cancer. In >85% cancer cells, telomere length is maintained by telomerase that add telomere repeats to the end of telomere DNA. Because the G-rich strand of telomere DNA can fold into G-quadruplex that inhibits telomer...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1888815/ https://ncbi.nlm.nih.gov/pubmed/17426118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm194 |
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