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G-quadruplex preferentially forms at the very 3′ end of vertebrate telomeric DNA
Human chromosome ends are protected with kilobases repeats of TTAGGG. Telomere DNA shortens at replication. This shortening in most tumor cells is compensated by telomerase that adds telomere repeats to the 3′ end of the G-rich telomere strand. Four TTAGGG repeats can fold into G-quadruplex that is...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2275102/ https://ncbi.nlm.nih.gov/pubmed/18158301 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm1137 |
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