Structure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K(+) solution: insights into the interconversion of human telomeric G-quadruplex structures

Human telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. The telomeric sequence shows intrinsic structure polymorphism. Here we report a novel intramolecular G-quadruplex structure formed by a variant human telomeric sequence in K(+) solution....

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Hlavní autoři: Zhang, Zhenjiang, Dai, Jixun, Veliath, Elizabeth, Jones, Roger A., Yang, Danzhou
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2010
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817458/
https://ncbi.nlm.nih.gov/pubmed/19946019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1029
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