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An exonuclease I hydrolysis assay for evaluating G-quadruplex stabilization by small molecules

Telomere length homeostasis is a prerequisite for the generation and growth of cancer. In >85% cancer cells, telomere length is maintained by telomerase that add telomere repeats to the end of telomere DNA. Because the G-rich strand of telomere DNA can fold into G-quadruplex that inhibits telomer...

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Bibliografiske detaljer
Main Authors: Yao, Yuan, Wang, Quan, Hao, Yu-hua, Tan, Zheng
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1888815/
https://ncbi.nlm.nih.gov/pubmed/17426118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm194
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