Modification of the active site of Mycobacterium tuberculosis KatG after disruption of the Met-Tyr-Trp cross-linked adduct

Mycobacterium tuberculosis catalase-peroxidase (Mtb KatG) is a bifunctional enzyme that possesses both catalase and peroxidase activities and is responsible for the activation of the antituberculosis drug isoniazid. Mtb KatG contains an unusual adduct in its distal heme pocket that consists of the c...

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Bibliographic Details
Main Authors: Kapetanaki, Sofia M., Zhao, Xiangbo, Yu, Shengwei, Magliozzo, Richard S., Schelvis, Johannes P. M.
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885897/
https://ncbi.nlm.nih.gov/pubmed/17188362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2006.11.004
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