Iron Overload and Heart Fibrosis in Mice Deficient for Both β2-Microglobulin and Rag1

Genetic causes of hereditary hemochromatosis (HH) include mutations in the HFE gene, a β2-microglobulin (β2m)-associated major histocompatibility complex class I-like protein. Accordingly, mutant β2m(−/−) mice have increased intestinal iron absorption and develop parenchymal iron overload in the liv...

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Bibliografiske detaljer
Main Authors: Santos, Manuela M., de Sousa, Maria, Rademakers, Luke H. P. M., Clevers, Hans, Marx, J. J. M., Schilham, Marco W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2000
Fag:
Regular Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885749/
https://ncbi.nlm.nih.gov/pubmed/11106561
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