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CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype

CD137 has long been recognized as a costimulatory receptor for growth and functional maturation of recently activated T cells in the presence of T-cell receptor signal. In this report, we present the fact that, in the absence of MHC and antigen, triggering of CD137 by an agonist monoclonal antibody...

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Detalles Bibliográficos
Autores principales: Zhu, Yuwen, Zhu, Gefeng, Luo, Liqun, Flies, Andrew S., Chen, Lieping
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885532/
https://ncbi.nlm.nih.gov/pubmed/17244673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-10-043463
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