Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors

Treatment of advanced, poorly immunogenic tumors in animal models, considered the closest simulation available thus far for conditions observed in cancer patients, remains a major challenge for cancer immunotherapy. We reported previously that established tumors in mice receiving an agonistic mAb to...

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Autores principales: Wilcox, Ryan A., Flies, Dallas B., Zhu, Gefeng, Johnson, Aaron J., Tamada, Koji, Chapoval, Andrei I., Strome, Scott E., Pease, Larry R., Chen, Lieping
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2002
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC150893/
https://ncbi.nlm.nih.gov/pubmed/11877473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI14184
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