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Blockade of LIGHT/LTβ and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease

Previous studies have shown that blockade of LIGHT, a T cell costimulatory molecule belonging to the TNF superfamily, by soluble lymphotoxin β receptor–Ig (LTβR-Ig) inhibits the cytotoxic T lymphocyte (CTL) response to host antigenic disparities and ameliorates lethal graft-versus-host disease (GVHD...

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Bibliografske podrobnosti
Main Authors: Tamada, Koji, Tamura, Hideto, Flies, Dallas, Fu, Yang-Xin, Celis, Esteban, Pease, Larry R., Blazar, Bruce R., Chen, Lieping
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2002
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC150873/
https://ncbi.nlm.nih.gov/pubmed/11854328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI13604
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