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The p21(Waf1) pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO
The 8;21 translocation is a major contributor to acute myeloid leukemia (AML) of the M2 classification occurring in approximately 40% of these cases. Multiple mouse models using this fusion protein demonstrate that AML1-ETO requires secondary mutagenic events to promote leukemogenesis. Here, we show...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society of Hematology
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1885483/ https://ncbi.nlm.nih.gov/pubmed/17284535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-03-012575 |
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