AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: Implication in stepwise leukemogenesis and response to Gleevec

To explore the genetic abnormalities that cooperate with AML1-ETO (AE) fusion gene to cause acute myeloid leukemia (AML) with t(8;21), we screened a number of candidate genes and identified 11 types of mutations in C-KIT gene (mC-KIT), including 6 previously undescribed ones among 26 of 54 (48.1%) c...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Wang, Yue-Ying, Zhou, Guang-Biao, Yin, Tong, Chen, Bing, Shi, Jing-Yi, Liang, Wen-Xue, Jin, Xiao-Long, You, Jian-Hua, Yang, Guang, Shen, Zhi-Xiang, Chen, Jue, Xiong, Shu-Min, Chen, Guo-Qiang, Xu, Feng, Liu, Yi-Wei, Chen, Zhu, Chen, Sai-Juan
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2005
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545849/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15650049/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408831102
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