Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)

Iron is essential for many biological processes, including oxygen delivery, and its supply is tightly regulated. Hepcidin, a small peptide synthesized in the liver, is a key regulator of iron absorption and homeostasis in mammals. Hepcidin production is increased by iron overload and decreased by an...

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Main Authors: Peyssonnaux, Carole, Zinkernagel, Annelies S., Schuepbach, Reto A., Rankin, Erinn, Vaulont, Sophie, Haase, Volker H., Nizet, Victor, Johnson, Randall S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2007
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884690/
https://ncbi.nlm.nih.gov/pubmed/17557118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31370
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