The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo

NO plays critical roles in vascular function. We show that modulation of the eNOS serine 1179 (S1179) phosphorylation site affects vascular reactivity and determines stroke size in vivo. Transgenic mice expressing only a phosphomimetic (S1179D) form of eNOS show greater vascular reactivity, develop...

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Detalhes bibliográficos
Main Authors: Atochin, Dmitriy N., Wang, Annie, Liu, Victor W.T., Critchlow, Jeffrey D., Dantas, Ana Paula V., Looft-Wilson, Robin, Murata, Takahisa, Salomone, Salvatore, Shin, Hwa Kyoung, Ayata, Cenk, Moskowitz, Michael A., Michel, Thomas, Sessa, William C., Huang, Paul L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884686/
https://ncbi.nlm.nih.gov/pubmed/17557122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29877
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