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The Akt1-eNOS Axis Illustrates the Specificity of Kinase-Substrate Relationships in Vivo
Akt1 is critical for many in vivo functions; however, the cell-specific substrates responsible remain to be defined. Here, we examine the importance of endothelial nitric oxide synthase (eNOS) as an Akt1 substrate by generating Akt1-deficient mice (Akt1(−/−) mice) carrying knock-in mutations (serine...
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| 出版年: | Sci Signal |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4750881/ https://ncbi.nlm.nih.gov/pubmed/19654415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000343 |
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