The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo

NO plays critical roles in vascular function. We show that modulation of the eNOS serine 1179 (S1179) phosphorylation site affects vascular reactivity and determines stroke size in vivo. Transgenic mice expressing only a phosphomimetic (S1179D) form of eNOS show greater vascular reactivity, develop...

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Autori principali: Atochin, Dmitriy N., Wang, Annie, Liu, Victor W.T., Critchlow, Jeffrey D., Dantas, Ana Paula V., Looft-Wilson, Robin, Murata, Takahisa, Salomone, Salvatore, Shin, Hwa Kyoung, Ayata, Cenk, Moskowitz, Michael A., Michel, Thomas, Sessa, William C., Huang, Paul L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884686/
https://ncbi.nlm.nih.gov/pubmed/17557122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29877
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