The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo

NO plays critical roles in vascular function. We show that modulation of the eNOS serine 1179 (S1179) phosphorylation site affects vascular reactivity and determines stroke size in vivo. Transgenic mice expressing only a phosphomimetic (S1179D) form of eNOS show greater vascular reactivity, develop...

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Main Authors: Atochin, Dmitriy N., Wang, Annie, Liu, Victor W.T., Critchlow, Jeffrey D., Dantas, Ana Paula V., Looft-Wilson, Robin, Murata, Takahisa, Salomone, Salvatore, Shin, Hwa Kyoung, Ayata, Cenk, Moskowitz, Michael A., Michel, Thomas, Sessa, William C., Huang, Paul L.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2007
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884686/
https://ncbi.nlm.nih.gov/pubmed/17557122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29877
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