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Pharmacokinetics of fosfluconazole and fluconazole following multiple intravenous administration of fosfluconazole in healthy male volunteers

AIMS: To assess the bioavailability of fluconazole (FLCZ) from phosphate pro-drug (fosfluconazole), to investigate the effect of loading doses on the time to achieve FLCZ steady state plasma concentrations and on safety, and to investigate the pharmacokinetics of fosfluconazole following once daily...

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Autors principals: Sobue, Satoshi, Tan, Keith, Layton, Gary, Eve, Malcolm, Sanderson, J Brian
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884549/
https://ncbi.nlm.nih.gov/pubmed/15206988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2004.02107.x
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