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Population pharmacokinetics of phenytoin after intravenous administration of fosphenytoin sodium in pediatric patients, adult patients, and healthy volunteers

PURPOSE: We performed a population pharmacokinetic analysis of phenytoin after intravenous administration of fosphenytoin sodium in healthy, neurosurgical, and epileptic subjects, including pediatric patients, and determined the optimal dose and infusion rate for achieving the therapeutic range. MET...

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Detalhes bibliográficos
Main Authors: Tanaka, Jun, Kasai, Hidefumi, Shimizu, Kenji, Shimasaki, Shigeki, Kumagai, Yuji
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572369/
https://ncbi.nlm.nih.gov/pubmed/22918614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-012-1373-8
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