Phenytoin pharmacokinetics and clinical effects in African children following fosphenytoin and chloramphenicol coadministration

AIMS: Some children with malaria and convulsions also have concurrent bacterial meningitis. Chloramphenicol is used to treat the latter whereas phenytoin is used for convulsions. Since chloramphenicol inhibits the metabolism of phenytoin in vivo, we studied the effects of chloramphenicol on phenytoi...

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Main Authors: Ogutu, Bernhards R, Newton, Charles R J C, Muchohi, Simon N, Otieno, Godfrey O, Kokwaro, Gilbert O
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2002
Teme:
Pharmacokinetics/Pharmacodynamics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874507/
https://ncbi.nlm.nih.gov/pubmed/12492612
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