CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide

AIMS: To identify the principal human cytochrome P450 (CYP) enzyme(s) responsible for the human in vitro biotransformation of repaglinide. Previous experiments have identified CYP3A4 as being mainly responsible for the in vitro metabolism of repaglinide, but the results of clinical investigations ha...

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Detalhes bibliográficos
Main Authors: Bidstrup, Tanja Busk, Bjørnsdottir, Inga, Sidelmann, Ulla Grove, Thomsen, Mikael Søndergård, Hansen, Kristian Tage
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2003
Assuntos:
Pharmacokinetics and Drug Disposition
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884358/
https://ncbi.nlm.nih.gov/pubmed/12919179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.0306-5251.2003.01862.x
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