Lack of pharmacokinetic interaction between retigabine and phenobarbitone at steady-state in healthy subjects

AIMS: To evaluate potential pharmacokinetic interactions between phenobarbitone and retigabine, a new antiepileptic drug. METHODS: Fifteen healthy men received 200 mg of retigabine on day 1. On days 4–32, phenobarbitone 90 mg was administered at 22.00 h. On days 26–32, increasing doses of retigabine...

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Bibliographic Details
Main Authors: Ferron, Geraldine M, Patat, Alain, Parks, Virginia, Rolan, Paul, Troy, Steven M
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2003
Subjects:
Pharmacokinetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884339/
https://ncbi.nlm.nih.gov/pubmed/12848774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2003.01825.x
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