Population pharmacokinetics and concentration–effect relationships of capecitabine metabolites in colorectal cancer patients

AIMS: To assess the relationship between systemic exposure to capecitabine metabolites and parameters of efficacy and safety in patients with advanced or metastatic colorectal cancer from two phase III studies. METHODS: Concentration–effect analyses were based on data from 481 patients (248 males, 1...

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Главные авторы: Gieschke, Ronald, Burger, Hans-Ulrich, Reigner, Bruno, Blesch, Karen S, Steimer, Jean-Louis
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Science Inc 2003
Предметы:
Pharmacokinetics/Pharmacodynamics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884209/
https://ncbi.nlm.nih.gov/pubmed/12630975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2003.01765.x
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