Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds.

Synthesis of influenza virus mRNA is primed by capped and methylated (cap 1, m7GpppXm) RNAs which the virus derives by endonucleolytic cleavage from RNA polymerase II transcripts in host cells. The conserved nature of the endonucleolytic processing provides a unique target for the development of ant...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Tomassini, J, Selnick, H, Davies, M E, Armstrong, M E, Baldwin, J, Bourgeois, M, Hastings, J, Hazuda, D, Lewis, J, McClements, W
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC188292/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7695269/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.12.2827
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