Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds.

Synthesis of influenza virus mRNA is primed by capped and methylated (cap 1, m7GpppXm) RNAs which the virus derives by endonucleolytic cleavage from RNA polymerase II transcripts in host cells. The conserved nature of the endonucleolytic processing provides a unique target for the development of ant...

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書誌詳細

出版年:	Antimicrob Agents Chemother
主要な著者:	Tomassini, J, Selnick, H, Davies, M E, Armstrong, M E, Baldwin, J, Bourgeois, M, Hastings, J, Hazuda, D, Lewis, J, McClements, W
フォーマット:	Artigo
言語:	Inglês
出版事項:	American Society for Microbiology (ASM) 1994
主題:	Research Article
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC188292/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7695269/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.12.2827
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