PERK mediates cell-cycle exit during the mammalian unfolded protein response

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR)-signaling pathway. The UPR coordinates the induction of ER chaperones with decreased protein synthesis and growth arrest in the G(1) phase of the cell cycle. Three ER transmembrane pr...

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Main Authors: Brewer, Joseph W., Diehl, J. Alan
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences 2000
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC18814/
https://ncbi.nlm.nih.gov/pubmed/11035797
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