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Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression

Alterations in normal protein biogenesis and the resulting accumulation of improperly folded proteins in the endoplasmic reticulum (ER) trigger a stress response that up-regulates the expression of ER chaperones, while coordinately repressing overall protein synthesis and causing cell-cycle arrest....

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Bibliografske podrobnosti
Main Authors: Brewer, Joseph W., Hendershot, Linda M., Sherr, Charles J., Diehl, J. Alan
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1999
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC17546/
https://ncbi.nlm.nih.gov/pubmed/10411905
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