Identification of highly potent and selective inhibitors of Toxoplasma gondii dihydrofolate reductase.
Toxoplasma gondii RH was obtained in high yield from culture in RPMI medium on a line of Chinese hamster ovary cells lacking dihydrofolate reductase activity (ATCC 3952 dhfr-; American Type Culture Collection). Dihydrofolate reductase preparations from harvested organisms had specific activities of...
Guardat en:
| Publicat a: | Antimicrob Agents Chemother |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
1993
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC188092/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8239605/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.9.1914 |
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