Identification of highly potent and selective inhibitors of Toxoplasma gondii dihydrofolate reductase.

Toxoplasma gondii RH was obtained in high yield from culture in RPMI medium on a line of Chinese hamster ovary cells lacking dihydrofolate reductase activity (ATCC 3952 dhfr-; American Type Culture Collection). Dihydrofolate reductase preparations from harvested organisms had specific activities of...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Chio, L C, Queener, S F
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1993
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC188092/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8239605/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.9.1914
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