Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis

Bone is accrued and maintained primarily through the coupled actions of bone-forming osteoblasts and bone-resorbing osteoclasts. Cumulative in vitro studies indicated that proline-rich tyrosine kinase 2 (PYK2) is a positive mediator of osteoclast function and activity. However, our investigation of...

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Hlavní autoři: Buckbinder, Leonard, Crawford, David T., Qi, Hong, Ke, Hua Zhu, Olson, Lisa M., Long, Kelly R., Bonnette, Peter C., Baumann, Amy P., Hambor, John E., Grasser, William A., Pan, Lydia C., Owen, Thomas A., Luzzio, Michael J., Hulford, Catherine A., Gebhard, David F., Paralkar, Vishwas M., Simmons, Hollis A., Kath, John C., Roberts, W. Gregory, Smock, Steven L., Guzman-Perez, Angel, Brown, Thomas A., Li, Mei
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1880863/
https://ncbi.nlm.nih.gov/pubmed/17537919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701421104
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