Structural Characterization of Proline-rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor Design

Proline-rich tyrosine kinase 2 (PYK2) is a cytoplasmic, non-receptor tyrosine kinase implicated in multiple signaling pathways. It is a negative regulator of osteogenesis and considered a viable drug target for osteoporosis treatment. The high-resolution structures of the human PYK2 kinase domain wi...

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Detalhes bibliográficos
Main Authors: Han, Seungil, Mistry, Anil, Chang, Jeanne S., Cunningham, David, Griffor, Matt, Bonnette, Peter C., Wang, Hong, Chrunyk, Boris A., Aspnes, Gary E., Walker, Daniel P., Brosius, Arthur D., Buckbinder, Leonard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676051/
https://ncbi.nlm.nih.gov/pubmed/19244237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809038200
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