A major role for Scar/WAVE-1 downstream of GPVI in platelets

BACKGROUND: The small GTPase Rac1 plays a critical role in lamellipodia assembly in platelets on matrix proteins in the absence or presence of G protein-coupled receptor (GPCR) agonists. Rac mediates actin assembly via Scar/WAVE, a family of scaffolding proteins that direct actin reorganization by r...

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Hlavní autoři: Calaminus, Simon D.J., McCarty, Owen J.T., Auger, Jocelyn M., Pearce, Andrew C., Insall, Robert H., Watson, Steve P., Machesky, Laura M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1880834/
https://ncbi.nlm.nih.gov/pubmed/17319906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2007.02377.x
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