Single 8-oxo-guanine and 8-oxo-adenine lesions induce marked changes in the backbone structure of a 25-base DNA strand

Structural changes in a 25-base DNA strand, induced by single 8-oxo-guanine or 8-oxo-adenine substitutions, were shown by using Fourier transform-infrared spectroscopy with multivariate statistics. Pronounced differences were demonstrated between the parent and derivatives with respect to base inter...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Malins, Donald C., Polissar, Nayak L., Ostrander, Gary K., Vinson, Mark A.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2000
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18782/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11058168/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.230438797
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