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Structural and Dynamic Features of the Recognition of 8-oxoguanosine Paired with an 8-oxoG-clamp by Human 8-oxoguanine-DNA Glycosylase

8-oxoguanine (oxoG) is formed in DNA by the action of reactive oxygen species. As a highly mutagenic and the most common oxidative DNA lesion, it is an important marker of oxidative stress. Human 8-oxoguanine-DNA glycosylase (OGG1) is responsible for its prompt removal in human cells. OGG1 is a bifu...

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Principais autores: Maria V. Lukina, Polina V. Zhdanova, Vladimir V. Koval
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-04-01
Serier:Current Issues in Molecular Biology
Fag:
DNA damage recognition
8-oxoguanosine
protein–DNA interaction
cytosine analog
MD simulations
Online adgang:https://www.mdpi.com/1467-3045/46/5/253
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