Structural and Dynamic Features of the Recognition of 8-oxoguanosine Paired with an 8-oxoG-clamp by Human 8-oxoguanine-DNA Glycosylase
8-oxoguanine (oxoG) is formed in DNA by the action of reactive oxygen species. As a highly mutagenic and the most common oxidative DNA lesion, it is an important marker of oxidative stress. Human 8-oxoguanine-DNA glycosylase (OGG1) is responsible for its prompt removal in human cells. OGG1 is a bifu...
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| Format: | Artigo |
| Sprache: | Inglês |
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MDPI AG
2024-04-01
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| Schriftenreihe: | Current Issues in Molecular Biology |
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| Online-Zugang: | https://www.mdpi.com/1467-3045/46/5/253 |
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