Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases

Bisphosphonate drugs (e.g., Fosamax and Zometa) are thought to act primarily by inhibiting farnesyl diphosphate synthase (FPPS), resulting in decreased prenylation of small GTPases. Here, we show that some bisphosphonates can also inhibit geranylgeranyl diphosphate synthase (GGPPS), as well as undec...

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Detalhes bibliográficos
Main Authors: Guo, Rey-Ting, Cao, Rong, Liang, Po-Huang, Ko, Tzu-Ping, Chang, Tao-Hsin, Hudock, Michael P., Jeng, Wen-Yih, Chen, Cammy K.-M., Zhang, Yonghui, Song, Yongcheng, Kuo, Chih-Jung, Yin, Fenglin, Oldfield, Eric, Wang, Andrew H.-J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1877987/
https://ncbi.nlm.nih.gov/pubmed/17535895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702254104
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